Chitosan osteoarthritis gene delivery

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August undefined, 2024

WebJan 28, 2024 · Chitosan is considered as an ideal material for hydrogels for its biocompatibility, progressive degradability, non-toxic, biological activity, anti-inflammatory …

Chitosan-Based Systems for Gene Delivery SpringerLink

WebChitosan–pDNA nanoparticle characteristics determine the transfection efficacy of gene delivery to human mesenchymal stem cells E Malakooty Poor, M Baghaban Eslaminejad, N Gheibi, F Bagheri, ... Artificial cells, nanomedicine, and biotechnology 42 (6), 376-384 , 2014 WebJan 2, 2014 · The present study was designed to develop and evaluate the chitosan-graft-polyethylenimine (CP)/DNA nanoparticles as novel non-viral gene vectors for gene … lth 301 32

Novel hyaluronic acid-chitosan nanoparticles as non-viral gene …

WebConventional treatments for osteoarthritis (OA), including drug delivery and tissue engineering approaches, could not offer a high yield of cartilage repair due to the compact and exclusive structure of cartilage. Targeted and high-efficiency delivery of gene sequences is necessary to rebalance the lost homeostatic properties of the cartilage ... WebJan 1, 2024 · The chitosan-based gene delivery system has several characteristics such as insignificant cellular toxicity, high gene delivery ability, targeting of particular cells, … WebJun 6, 2024 · Chitosan is a linear copolymer composed by glucosamine and N -acteyl glucosamine units, via β- (1, 4) linkages, namely 2-amino-2-deoxy-β-d-glucan (Fig. 2 a). Chitosan is the product of the deacetylation reaction of chitin (2-acetamido-2 … jdeveloper hang at restoring windows

Chondroprotective Effects of Hyaluronic Acid-Chitosan …

Chitosan in Biomedical Applications - 1st Edition - Elsevier

WebFeb 23, 2024 · Keywords: Osteoarthritis, Gene therapy, Chitosan, Hyaluronic acid, Chondroitin sulfate, Growth and differentiation factor-5 (GDF-5) plasmid. 1. ... HA and CHS enabled the non-viral vector itself to have some therapeutic effects on OA, making it much more suitable for delivery of gene therapy treatments for OA. WebConclusions: These results suggested that HA/CS-CrmA nanoparticles could attenuate cartilage destruction and protect against early OA by inhibiting synovial inflammation via … jdeveloper dark themeWebdesigned to develop and evaluate the chitosan-graft-polyethylenimine (CP)/DNA nanoparticles as novel non-viral gene vectors for gene therapy of osteoarthritis. jd estates liverpool walton

"WebApr 12, 2024 · Chitosan is a naturally occurring polysaccharide that is derived from chitin, a major component of the exoskeletons of crustaceans such as shrimp, crab, and lobster. It has been gaining attention in the field of biotechnology and biomedicine due to its unique properties and potential applications. Chitosan is a linear polysaccharide that consists of … " - Chitosan osteoarthritis gene delivery

Chitosan osteoarthritis gene delivery

Chitosan-Graft-Polyethylenimine/DNA Nanoparticles as Novel …

WebApr 11, 2024 · 1.3.1.Advantageous properties of chitosan as a biomaterial. Chitosan has a structure similar to that of glycine aminoglycan, which is widely distributed in connective tissue, giving chitosan good biocompatibility (Malafaya et al., 2007).Chitosan-based biomaterials do not cause cytotoxicity or genotoxicity and promote cell proliferation and … WebIntroduction. Cartilage injury, a common clinical problem, can be caused by trauma, 1 osteoarthritis, 2 rheumatoid arthritis, 3 and exfoliative chondritis. 4 Articular cartilage is …

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WebOct 16, 2024 · 2.2. CS-Based Modifications for Targeted Drug Delivery. When a drug enters the human body, various obstacles prevent it from reaching the disease site to elicit a specific therapeutic effect [].More importantly, drug often impart severe toxic side effects [].The current most effective strategy for solving the issues above mentioned is targeted … WebAug 31, 2024 · Chitosan-based carriers have been recently considered for transporting hydrophobic agents such as chemotherapeutic compounds, therapeutic peptides, and nucleic acids ( e.g. DNA and siRNA) [67], [68].

WebJun 1, 2024 · Chitosan is a natural polymer with inherent antibacterial activity and a hemostasis and wound healing acceleration capability, so it has been used in drug … WebAug 31, 2024 · Although gene delivery systems can be viral or non-viral, non-viral gene delivery materials are being specifically developed that could deliver the gene as a safer …

WebJan 2, 2014 · Abstract. The development of safe and efficient gene carriers is the key to the clinical success of gene therapy. The present study was designed to develop and … WebNov 28, 2011 · Gene therapy, which treats the causes of osteoarthritis by targeting specific pathological mechanisms, is attracting much attention as a promising new treatment …

WebThere are two main approaches for gene delivery using viral and non-viral gene transfer systems for treating articular cartilage defects in OA, or following joint trauma. The first is …

WebThingreila Muinao, ...Mintu Pal, in Polysaccharide Carriers for Drug Delivery, 2024. 15.4.2.9 Chondroitin sulfate. Chondroitin sulfate is a natural water soluble polymer comprising of repeating disaccharide units of d-glucuronic acid and N-acetylgalactosamine, sulfated at either 4- or 6-positions.While cross-linked chondroitin sulfates may show less hydrophilic … jdeveloper network interface selectionWebDec 17, 2024 · To construct a novel non-viral vector loaded with growth and differentiation factor-5 (GDF-5) plasmid using chitosan, hyaluronic acid, and chondroitin sulfate for osteoarthritis (OA) gene therapy. Methods Nano-microspheres (NMPs) were prepared by mixing chitosan, hyaluronic acid, and chondroitin sulfate. lth-301-32WebOsteoarthritis (OA) is a painful, degenerative and inflammatory disease that affects the entire synovial joints. Nowadays, no cure exists, and the pharmacological treatments … jde towards real-time multi-object tracking